Chofunikira chachikulu: Doxycycline hydrochloride

Katundu: Izi ndi zobiriwira zobiriwira.

Pharmacological zochita:

Pharmacodynamics:Izi ndi tetracycline yotakata sipekitiramu maantibayotiki ndi yotakata sipekitiramu antibacterial kwenikweni. Mabakiteriya okhudzidwa amaphatikizapo mabakiteriya a Gram-positive monga pneumococcus, streptococcus, staphylococcus, anthrax, tetanus, corynebacterium ndi mabakiteriya ena a gram-negative monga Escherichia coli, Pasteurella, Salmonella, Brucella ndi Haemophilus, Klebsiterella ndi memelelo. Ikhozanso kulepheretsa Rickettsia, mycoplasma ndi spirochaeta pamlingo wina.

Pharmacokinetics:Mayamwidwe mwachangu, kukhudzidwa pang'ono ndi chakudya, kupezeka kwakukulu kwa bioavailability. Magazi ogwira mtima amasungidwa kwa nthawi yayitali, kutsekemera kwa minofu kumakhala kolimba, kugawidwa kuli kwakukulu, ndipo n'kosavuta kulowa mu selo. Mlingo wokhazikika wagalu wagalu ndi pafupifupi 1.5L/kg. Kumanga mapuloteni apamwamba agalu 75% mpaka 86%. Pang'ono pomwe chelation m'matumbo, 75% ya galuyo imachotsedwa motere. Kutuluka kwa aimpso kumakhala pafupifupi 25%, kutulutsa kwa biliary kumakhala kosakwana 5%. Theka la moyo wa galu ndi pafupifupi maola 10 mpaka 12.

Kuyanjana ndi mankhwala:

(1) Mukatengedwa ndi sodium bicarbonate, imatha kuonjezera pH mtengo m'mimba ndikuchepetsa kuyamwa ndi kuchitapo kanthu kwa mankhwalawa.

(2) Izi zimatha kupanga ma complexes okhala ndi divalent ndi trivalent cations, etc., kotero akatengedwa ndi calcium, magnesium, aluminium ndi maantacid ena, mankhwala okhala ndi chitsulo kapena mkaka ndi zakudya zina, kuyamwa kwawo kumachepetsedwa, zomwe zimapangitsa kuchepa magazi mankhwala ndende.

(3) Kugwiritsa ntchito komweko ndi okodzetsa amphamvu monga furthiamide kumatha kukulitsa kuwonongeka kwa aimpso.

(4) Kodi kusokoneza bactericidal zotsatira za penicillin pa bakiteriya kuswana nthawi, ayenera kupewa ntchito yomweyo.

Zizindikiro:

Matenda a mabakiteriya abwino, mabakiteriya oipa ndi mycoplasma. Matenda opuma (mycoplasma chibayo, chlamydia chibayo, nthambi ya m'mphuno yamphongo, matenda a feline calicivirus, canine distemper). Dermatosis, genitourinary system, matenda am'mimba, etc.

Kagwiritsidwe ndi Mlingo:

Mankhwala "Doxycycline". Kwa makonzedwe amkati: mlingo umodzi, 5 ~ 10mg pa 1kg thupi la agalu ndi amphaka. Amagwiritsidwa ntchito kamodzi pa tsiku kwa masiku 3-5. Kapena monga momwe adanenera dokotala. Ndibwino kuti mutenge mutatha kudyetsa ndi kumwa madzi ambiri mutatha kumwa.

Chenjezo:

(1) Sizovomerezeka kwa agalu ndi amphaka pasanathe milungu itatu asanabadwe, kuyamwitsa, ndi mwezi umodzi.

(2) Gwiritsani ntchito mosamala agalu ndi amphaka omwe ali ndi vuto lalikulu la chiwindi ndi impso.

(3) Ngati mukufunikira kutenga calcium zowonjezera, zowonjezera zitsulo, mavitamini, maantacids, sodium bicarbonate, ndi zina zotero panthawi imodzimodziyo, chonde osachepera 2h interval.

(4) Ndi zoletsedwa kugwiritsa ntchito mankhwala okodzetsa ndi penicillin.

(5) Kuphatikizidwa ndi phenobarbital ndi anticoagulant kudzakhudza ntchito ya wina ndi mzake.

Zotsatira zoyipa:

(1) Mwa agalu ndi amphaka, zotsatira zoyipa kwambiri za oral doxycycline ndi kusanza, kutsekula m'mimba, ndi kuchepa kwa njala. Pofuna kuchepetsa zotsatira zoyipa, palibe kuchepa kwakukulu kwa mayamwidwe a mankhwala omwe adawonedwa atatengedwa ndi chakudya.

(2) 40% ya agalu ochiritsidwa anali ndi kuwonjezeka kwa michere yokhudzana ndi chiwindi (alanine aminotransferase, basic conglutinase). Tanthauzo lachipatala la kuchuluka kwa ma enzyme okhudzana ndi chiwindi sikuwonekera bwino.

(3) Oral doxycycline ingayambitse esophageal stenosis mu amphaka, monga mapiritsi apakamwa, iyenera kutengedwa ndi madzi osachepera 6ml, osati owuma.

(4) Kuchiza ndi tetracycline (makamaka nthawi yayitali) kungayambitse kuwonjezereka kwa mabakiteriya osamva kapena bowa (matenda aŵiri).

Zolinga: Kwa amphaka ndi agalu okha.

Kufotokozera: 200 mg / piritsi