Demenidazole, monga m'badwo woyamba wa antigenic tizilombo mankhwala, mtengo wake otsika zimapangitsa kuti chimagwiritsidwa ntchito Chowona Zanyama matenda matenda ndi mankhwala. Komabe, pogwiritsa ntchito mankhwala amtundu wotere komanso m'mbuyo komanso m'badwo woyambirira wa nitroimidazoles, vuto la kukana kwa mankhwala pogwiritsira ntchito lidzakhala lodziwika kwambiri.

01Anti anaerobic effect

Komabe, kugwiritsidwa ntchito kwake kwakukulu mukupanga nkhuku kumawonekera makamaka mu anti anaerobic bacteria. M'zaka makumi angapo zapitazi, akhala akugwiritsidwa ntchito kwambiri pochiza nkhuku necrotic enteritis, enterotoxic syndrome ndi kutupa kwa oviduct. Komabe, kukhudzika kwake kwa anaerobes kukukulirakulira. Chifukwa chake ndi: kwa nthawi yayitali m'mbuyomu, kuzunzidwa ndi kugwiritsiridwa ntchito kosavomerezeka kwapangitsa kuti mabakiteriya ambiri a anaerobic achuluke chaka ndi chaka, ndipo kuyang'anira kukuchitikabe. Pofuna kuthana ndi chitukuko choyipachi, dipatimenti yodziwa bwino zachipatala yaziletsa zaka khumi zapitazo: itha kugwiritsidwa ntchito pakuweta ndi kupanga nyama zomwe zimagwiritsidwa ntchito kwambiri, ndipo zitha kugwiritsidwa ntchito kuswana ziweto ndi nkhuku, ziweto ndi zina zosagwirizana ndi zakudya zapadera.

02Kugwirizana kwasayansi ndi koyenera

Pankhani ngakhale zosayenera ntchito demenidazole, choyamba, sayenera kugwiritsidwa ntchito limodzi ndi methamphenicol, florfenicol ndi mankhwala ena amido mowa, chifukwa demenidazole angayambitse m`mafupa dysplasia mu ziweto ndi nkhuku, ndipo pamene ntchito pamodzi ndi pamwamba. amido mowa maantibayotiki, zidzawonjezera chiopsezo cha zotsatira zoyipa m'magazi.

Kachiwiri, sayenera kugwiritsidwa ntchito ndi Mowa kapena kukonzekera munali wambirimbiri Mowa, chifukwa kuphatikiza awiri kuchititsa disulfiram anachita, ndi odwala nyama angakhale ndi zizindikiro za minyewa matenda. Komanso, kugwiritsa ntchito mowa kapena mankhwala okhala ndi mowa wambiri kuyenera kuchepetsedwa momwe mungathere mkati mwa masiku 7-10 mutasiya mankhwala.

Chachitatu, makamaka kwa Pet Medical makampani, choyamba, sayenera pamodzi ndi immunosuppressive mankhwala, apo ayi, demenidazole akhoza ziletsa zotsatira za mycophenolate mofetil pa thupi. Chachiwiri, sichingagwiritsidwe ntchito ndi ma anticoagulants amkamwa, omwe amathandizira kuti ma anticoagulants a oral anticoagulants monga warfarin asagwiritsidwe ntchito, kuti ziweto zikhale ndi chiopsezo chotaya magazi.

Pomaliza, izi zili makamaka m'makampani azachipatala a ziweto. Choyamba, izo sizingakhoze pamodzi ndi chiwindi mankhwala enzyme inhibitors. Mwachitsanzo, chiwindi mankhwala enzyme inhibitors monga cimetidine akhoza ziletsa kagayidwe wa metronidazole. Pamene pamodzi, m`pofunika kudziwa magazi mankhwala ndende ndi kusintha mlingo yomweyo. Chachiwiri ndi chakuti sichingagwiritsidwe ntchito ndi inducers ya hepatic drug enzyme. Pamene pamodzi ndi kwa chiwindi mankhwala enzyme inducers monga phenytoin, kagayidwe demenidazole adzakhala inapita patsogolo ndi plasma ndende adzakhala yafupika; Kagayidwe ka phenytoin ndi ma inducers ena a hepatic enzyme inducers adachedwetsa ndipo ndende ya plasma idakula.

03Kukonzekera kumakhudza kuchiritsa kwenikweni

Chifukwa demenidazole palokha sungunuka pang'ono m'madzi ndipo ndi nthawi amadalira mankhwala, zofooka zake mankhwala ndi pharmacodynamic makhalidwe zimatsimikizira kuti "kukonza chimatsimikizira lapamwamba". Nthawi zambiri timawona mu udzu-mizu mayunitsi kuti solubility wa dimenidazole premix mankhwala makamaka osauka. Pambuyo powonjezera madzi ambiri ndi kusakaniza mokwanira, pali "chiwerengero chambiri chosasungunuka" mumchenga wabwino kwambiri. Izi sizomwe opanga amapanga kuti atchule vuto la khalidwe la madzi, kapena kunena zabodza kuti zinthu zosasungunuka ndizo zowonjezera ndi zina zomwe siziri mankhwala.

Zogulitsa zotere zosakanikirana za dimenidazole, kuphatikiza zotsika mtengo komanso zotsika mtengo, ndizogwirizana "palibe zotsatira".

Choncho, ambiri a udzu-mizu alimi ndi Chowona Zanyama owerenga mankhwala ayenera kulabadira "zapamwamba" mankhwala ndi zokwanira mankhwala okhutira ndi solubility wabwino posankha dimenidazole premix mankhwala zochizira matenda anaerobic m`mimba thirakiti kapena ubereki dongosolo. Kuphatikiza pa kusankha mankhwala, chinthu chofunikira kwambiri ndi ichi: molingana ndi cholinga chenicheni chakukulitsa kusamva kwa mankhwala, tiyenera kuchita ntchito yabwino kuphatikiza, kugwirizanitsa ndi kugwiritsa ntchito mogwirizana kwa anti drug resistance, kuti tipititse patsogolo ndikuwonetsa "Kuchita bwino" kwa chithandizo chamankhwala.