Ma sulfonamides ali ndi ubwino wambiri wa antibacterial sipekitiramu, katundu wokhazikika, mtengo wotsika komanso zosiyanasiyana zokonzekera zomwe mungasankhe. Mapangidwe a sulfonamides ndi p-sulfanilamide. Ikhoza kusokoneza kaphatikizidwe ka bakiteriya kupatsidwa folic acid ndi kukhudza kukula kwake ndi kubereka, potero kulepheretsa mabakiteriya ambiri a gram-positive ndi mabakiteriya ena oipa.

Mabakiteriya omwe amakhudzidwa kwambiri ndi sulfa ndi awa: Streptococcus, Pneumococcus, Salmonella, ndi zina zotero, ndipo okhudzidwa kwambiri ndi awa: Staphylococcus, Escherichia coli, Pasteurella, Shigella, Listeria, Actinomyces ena ndi Treponema hyodysenteriae Komanso amakhudzidwa ndi sulfonamides; imathandizanso polimbana ndi protozoa monga coccidia. Mabakiteriya omwe amakhudzidwa ndi sulfonamides amatha kukana.

Pogwiritsidwa ntchito, sulfonamides nthawi zambiri amagwiritsidwa ntchito limodzi ndi mankhwala ena. Mavuto ambiri obwera chifukwa chogwiritsa ntchito nthawi yayitali ma sulfonamides ndi kusokonezeka kwa kwamikodzo, kuwonongeka kwa aimpso komanso kuchepa kwa chakudya.

Pofuna kuchepetsa poizoni ndi zotsatira zake, choyamba, mlingo uyenera kukhala woyenera, ndipo sayenera kuwonjezereka kapena kuchepetsedwa mwakufuna kwake. Ngati mlingowo ndi waukulu kwambiri, umawonjezera poizoni ndi zotsatira zake, ndipo ngati mlingowo ndi wochepa kwambiri, sudzakhala ndi zotsatira zochiritsira zokha, koma zidzachititsa kuti mabakiteriya a pathogenic ayambe kukana mankhwala. Chachiwiri, ntchito ndi mankhwala ena, monga amproline ndi sulfonamide synergists, kuchepetsa mlingo. Chachitatu, ngati chilinganizo chilola, mulingo wofanana wa sodium bicarbonate ukhoza kuwonjezeredwa. Chachinayi, mabakiteriya amatha kupanga milingo yosiyana ya kukana mankhwala a sulfa, choncho ngati samva mankhwala enaake a sulfa, sikoyenera kusinthira ku mankhwala ena a sulfa. Nthawi zambiri, mlingo woyambirira wa mankhwala a sulfa uyenera kuwirikiza kawiri, ndipo pakatha nthawi yovuta, mankhwalawa ayenera kuumirira kwa masiku 3-4 asanayambe kuyimitsa.